Concentrations of IL-8 in CSF were significantly higher in LDH patients compared to DDD patients and controls
.•In LDH patients there was a positive correlation of IL-8 concentrations between CSF and serum.
•Elevated IL-8 in CSF was associated with increased pain intensity and spinal pressure pain sensitivity in LDH.
•IL-6, IL-8 and TSPO expression in IVD was higher in DDD patients compared to LDH.
•TSPO gene expression in IVDs was associated with higher back pain intensity in LDH patients.
Characterization of neuroinflammation and periphery-to-CNS inflammatory cross-talk in patients with disc herniation and degenerative disc disease
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