- •Botulinum toxin type A is slightly more effective than placebo for pain reduction at 1 month.
- •Botulinum toxin type A does not increase the risk of adverse events.
- •Low certainty evidence limits our confidence in effect estimates.
BTX-A was similar to no treatment for pain reduction at 3 and 6 months. BTX-A was more effective than conventional treatment and low-level laser therapy for pain reduction at 1, 6, and 12 months, but less effective than facial manipulation for pain reduction at 3 months
Botulinum Toxin Type A for Painful Temporomandibular Disorders: Systematic Review and Meta-Analysis
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