A Mediational Analysis of Stress, Inflammation, Sleep, and Pain in Acute Musculoskeletal Trauma "In this study, participant ratings of mean general life stress in the 6 months prior to non-catastrophic MSK trauma significantly predicted baseline pain severity as measured using the BPI Pain Severity subscale. Pre-trauma life stress also predicted the score on the BPI Sleep Interference item captured within 3 weeks of trauma, and predicted post-trauma [CRP] in an inverse relationship. Through mediational path analysis, the relationship between stress and pain was fully mediated by sleep interference while CRP did not affect the relationship."
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