Effects of in vivo fatigue-induced subchondral bone microdamage on the mechanical response of cartilage-bone under a single impact compression Results indicated that stiffness of cartilage-bone and those associated with the SCB decreased with increasing grade of damage. Whole specimen stiffness also increased, and relative energy loss decreased with higher TMD, whereas bone volume fraction of the SCB was only associated negatively with the stiffness of the bone. Overall, the degree of subchondral bone damage observed with µCT was the main predictor of stiffness and relative energy loss of the articular surface of the third metacarpal bone of Thoroughbred racehorses under impact loading.
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