Alcohol and Human Health: What Is the Evidence? 1. Alcohol has been consumed for a very long time, and its types and patterns of consumption vary widely. Moderate alcohol consumption is defined as one US glass (14 g alcohol) per day for women and two US glasses (28 g alcohol) per day for men. 2. Light and moderate drinkers have a reduced risk for mortality, whereas heavy drinkers, binge drinkers, and alcohol abusers have an increased risk. 3. Moderate alcohol consumption is associated with a risk reduction of approximately 30% for CVDs, approximately 30% for type-2 diabetes, and approximately 25% for dementia. 4. Heavy alcohol consumption for several decades leads to AUD. Lifetime prevalence of AUD in the United States is estimated to be almost 30% on the basis of DSM-5 criteria. 5. AUD is associated with increased risk of alcoholic liver disease, malnutrition, CVD, pancreatitis, cancers, diseases of the brain, and FASD.
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