Disruptions of Awake Glutamate Signaling in Two Models of Migraine Glutamate imaging confirms the FHM2 mutation alters glutamate signaling during cortical processing and uncovers a non‐canonical form of glutamate release in FHM2 and CSD. The occurrence of plumes in both a genetic and a physiological model of migraine suggests a broader relevance to the disorder, though further work is needed to understand the mechanism and extent of these events.
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