Have We Looked in the Wrong Direction for More Than 100 Years? Delayed Onset Muscle Soreness Is, in Fact, Neural Microdamage Rather Than Muscle Damage The variability of timelines and symptoms of DOMS, after initiation, will depend on how pervasive the injury is to the surrounding tissues and what tissues are affected. The individual differences could be explained by the complexity of pathways and cross-talking of the microinjured tissues and immune systems. The type and duration of eccentric exercise, trained status, age, genetics, and underlying allergies and low-grade inflammation or diseases could also affect the timelines and the extent of symptoms in DOMS.
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