I Want to Hold Your Hand (to Ease the Pain)
"López-Solà believes there is a strong central component to the phenomenon of handholding analgesia.“It’s hard to say conclusively whether or not the results are driven in part by peripheral input. However, the strong involvement of multiple limbic and neocortical regions that we see should be less directly influenced by pain primary afferents,” López-Solà said. “They require contextual information, such as meaning and representation of your romantic partner, which the brain is better able to encode compared to the periphery.”
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