Paracetamol and pain: the kiloton problem Patients with pain regard only large reductions in that pain to be relevant, and large reductions in pain are accompanied by major improvements in associated symptoms, including quality of life, function and work, and lower costs to health services.19 ,20 We know that only a minority of patients have adequate pain relief on any particular drug.21 We know that the majority of people with chronic pain still have moderate or severe pain while on treatment, indicating that treatment to be inadequate.22 We know that switching to another medicine in that situation results in major benefits for many.23
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