Research Posts

The compelling link between physical activity and the body’s defense system
The compelling link between physical activity and the body's defense system The future of exercise immunology will take advantage of advances in mass spectrometry and genetic testing technology, with increased utilization of metabolomics, proteomics, lipidomics, microbiome characterization, and genomics. Use of these system-wide approaches will provide new insights on the interactions between exercise, nutrition, and […]
What Type of Exercise Is Most Effective for People With Knee Osteoarthritis and Co-Morbid Obesity?: The TARGET Randomized Controlled Trial
What Type of Exercise Is Most Effective for People With Knee Osteoarthritis and Co-Morbid Obesity?: The TARGET Randomized Controlled Trial Both exercise types similarly improved primary outcomes of pain and function and can be recommended for people with knee OA and obesity. WB exercise may be preferred given fewer adverse events and potential additional benefits […]
Global, regional, and national burden of neck pain in the general population, 1990-2017: systematic analysis of the Global Burden of Disease Study 2017
Global, regional, and national burden of neck pain in the general population, 1990-2017: systematic analysis of the Global Burden of Disease Study 2017 Neck pain is a serious public health problem in the general population, with the highest burden in Norway, Finland, and Denmark. Increasing population awareness about risk factors and preventive strategies for neck […]
Results of a Patient-Oriented Second Opinion Program in Germany Shows a High Discrepancy Between Initial Therapy Recommendation and Second Opinion
Results of a Patient-Oriented Second Opinion Program in Germany Shows a High Discrepancy Between Initial Therapy Recommendation and Second Opinion The second opinion offers patients the possibility to confirm a medical indication independently and support patients in their decision making process. Reasons for the large discrepancy between initial therapy recommendation and second opinion should be […]
Optimal Human Functioning Requires Exercise Across the Lifespan: Mobility in a 1g Environment Is Intrinsic to the Integrity of Multiple Biological Systems
Optimal Human Functioning Requires Exercise Across the Lifespan: Mobility in a 1g Environment Is Intrinsic to the Integrity of Multiple Biological Systems Sedentary behavior and a lack of a minimal or reinforcing loading may allow for exercise/loading-inhibited otherwise “silent” mutations in our genomes to overcome such inhibition and contribute to senescence, and what we now […]
Uncertainty and stress: Why it causes diseases and how it is mastered by the brain
Uncertainty and stress: Why it causes diseases and how it is mastered by the brain Accordingly, in times of uncertainty, the selfish brain demands extra energy from the body. If, despite all this, the brain cannot reduce uncertainty, a persistent cerebral energy crisis may develop, burdening the individual by ‘allostatic load’ that contributes to systemic […]
Exercise for the Intervertebral Disc: A 6-month Randomised Controlled Trial in Chronic Low Back Pain
Exercise for the Intervertebral Disc: A 6-month Randomised Controlled Trial in Chronic Low Back Pain This trial found that 6 months of exercise did not benefit the IVD of people with NSCLBP. Based on this index study, future studies could investigate the effect of exercise on IVD in different populations, with different types, durations and/or […]
Best Evidence Rehabilitation for Chronic Pain Part 5: Osteoarthritis
Best Evidence Rehabilitation for Chronic Pain Part 5: Osteoarthritis Treatment strategies for OA pain should be broadened beyond a simple focus on the affected joint(s). While joint directed treatments remain sensible, it is important to screen for, recognize, and appropriately manage other factors (e.g., central sensitization, psychosocial factors, sleep problems) that may be contributing to […]
A Systematic Review of Workplace Interventions to Rehabilitate Musculoskeletal Disorders Among Employees with Physical Demanding Work
A Systematic Review of Workplace Interventions to Rehabilitate Musculoskeletal Disorders Among Employees with Physical Demanding Work The systematic search revealed 54 suitable high or moderate quality workplace-studies (36 RCTs and 18 non-RCTs) that focused on MSD among workers with physically demanding employment, which served as a solid foundation for the evidence synthesis and the subsequent […]
Education as a strategy for managing occupational-related musculoskeletal pain: a scoping review
Education as a strategy for managing occupational-related musculoskeletal pain: a scoping review There is a gap in knowledge regarding the best content and delivery of education of material in the workplace. Although beneficial outcomes were reported, more RCT studies are required to determine the effects of education material as compared with other interventions, such as […]
Effectiveness of spinal manipulation and myofascial release compared with spinal manipulation alone on health-related outcomes in individuals with non-specific low back pain: randomized controlled trial
Effectiveness of spinal manipulation and myofascial release compared with spinal manipulation alone on health-related outcomes in individuals with non-specific low back pain: randomized controlled trial We demonstrated that spinal manipulation combined with myofascial release was not more effective compared to spinal manipulation alone for patients with CNLBP. #science #chiropractor #chiropractic #research #education #evidence based #patient […]
Factors associated with the prescribing of high-dose opioids in primary care: a systematic review and meta-analysis
Factors associated with the prescribing of high-dose opioids in primary care: a systematic review and meta-analysis High doses of opioids are associated with greater risks of harms. Associated factors such as the co-prescription of benzodiazepines and depression identify priority areas that should be considered when selecting, identifying, and managing people taking high-dose opioids in primary […]
Association between objectively measured physical behaviour and neck‐ and/or low back pain: A systematic review
Association between objectively measured physical behaviour and neck‐ and/or low back pain: A systematic review This review indicates that, among blue‐collar workers, increased sitting at work may protect against NP and LBP while increased physical activity during work and/or leisure may increase this risk. There was no evidence supporting physical activity as a prognostic factor […]
Effects of Low-Level Laser Therapy and Chiropractic Care on Back Pain in Quarter Horses
Effects of Low-Level Laser Therapy and Chiropractic Care on Back Pain in Quarter Horses The results of this study support the concept that a multimodal approach of laser therapy and chiropractic care is beneficial in treating back pain in horses involved in active competition. #science #chiropractor #chiropractic #research #education #evidence based #patient centered #interprofessional #collaborative […]
What type of exercise is most effective for people with knee osteoarthritis and co-morbid obesity?: The TARGET randomized controlled trial
What type of exercise is most effective for people with knee osteoarthritis and co-morbid obesity?: The TARGET randomized controlled trial Both exercise types similarly improved primary outcomes of pain and function and can be recommended for people with knee OA and obesity. WB exercise may be preferred given fewer adverse events and potential additional benefits […]
Investigating musculoskeletal health and wellbeing; a cohort study protocol
Investigating musculoskeletal health and wellbeing; a cohort study protocol To conclude, IMH&W is a questionnaire-based cohort study which aims to elucidate associations and progression of pain, frailty and disability, to identify risk factors for poor outcomes and facilitate the execution and interpretation of research in order to improve outcome in specific populations where there is […]
A Humble Task: Restoring Virtue in an Age of Conflicted Interests
A Humble Task: Restoring Virtue in an Age of Conflicted Interests They further argue that humility must serve as a crowning virtue-not a meek humility but, rather, a courageous willingness to recognize one's own limitations and one's need to use "compensating strategies," such as time-outs and consultation with more objective others, when making decisions in […]
Prescribing and dosing exercise in primary care
Prescribing and dosing exercise in primary care Exercise prescription, although not part of the standard medical school curriculum, is now an essential skill in primary care. Exercise is an evidence-based treatment for osteoarthritis, back pain, tendinopathy, some cancers, depression, diabetes and cardiovascular diseases. It requires more than rudimentary understanding to successfully implement, as patients can […]
Evaluation and Treatment of Tandem Spinal Stenosis
Evaluation and Treatment of Tandem Spinal Stenosis For stenosis of the cervical spine, judicious decision making is required. The natural history of CSM is one of stepwise progression—surgical intervention does not necessarily lead to reversal of the deficit, and so, any delay in surgery exposes the patient to potentially further loss of function. Systematic reviews […]
Postsurgical rehabilitation for adults with low back pain with or without radiculopathy who were treated surgically: protocol for a mixed studies systematic review
Postsurgical rehabilitation for adults with low back pain with or without radiculopathy who were treated surgically: protocol for a mixed studies systematic review Findings from our review will guide future research by identifying both the methodological limitations of previous studies, and the knowledge gaps in the current scientific literature. Future studies can be designed to […]
Effect of an upright (vs. stooped) posture on interpretation bias, imagery, and emotions
Effect of an upright (vs. stooped) posture on interpretation bias, imagery, and emotions Posture interacts with mechanisms involved in the maintenance of depression, as well as with depression-related emotions. This study has clinical implications that should be continued explored in order to clarify the role of manipulating the posture in individuals with depressive symptomatology. #science […]
Overlapping, Masquerading, and Causative Cervical Spine and Shoulder Pathology: A Systematic Review
Overlapping, Masquerading, and Causative Cervical Spine and Shoulder Pathology: A Systematic Review Shoulder and spine pathology commonly overlap. Knowledge of anatomy, pain referral patterns, shoulder kinematics, and examination techniques are invaluable to the clinician in making an appropriate diagnosis and guiding treatment. In this review, we present an algorithm for the identification and treatment of […]
Fear of Pain and Pain Intensity: Meta-analysis and Systematic Review
Fear of Pain and Pain Intensity: Meta-analysis and Systematic Review The association turned out to be stable across different FOP measures, but was significantly moderated by age, pain localization, first-time pain episode, pain onset, treatment status, and anxiety sensitivity. A potentially necessary differentiation of patient subgroups and suggestions for an adjusted methodological approach of future […]
Alcohol and Human Health: What Is the Evidence?
Alcohol and Human Health: What Is the Evidence? 1. Alcohol has been consumed for a very long time, and its types and patterns of consumption vary widely. Moderate alcohol consumption is defined as one US glass (14 g alcohol) per day for women and two US glasses (28 g alcohol) per day for men. 2. […]
Digital Care for Chronic Musculoskeletal Pain: A 10,000 User Longitudinal Observational Study
Digital Care for Chronic Musculoskeletal Pain: A 10,000 User Longitudinal Observational Study These results support the efficacy and scalability of a DCP for chronic low back and knee pain in a large, diverse, real-world population. Participants demonstrated high completion and engagement rates, and a significant positive relationship between engagement and pain reduction was identified, a […]
Chronic Musculoskeletal Pain and Nutrition: Where Are We and Where Are We Heading?
Chronic Musculoskeletal Pain and Nutrition: Where Are We and Where Are We Heading? Based on the available literature, dietary behavior and quality could have an impact on chronic musculoskeletal pain conditions, but the direction of this impact is unclear. There is a need for additional human nutrition studies that focus on specific musculoskeletal pain conditions […]
A cross-sectional study of website claims related to diagnoses and treatment of nonmusculoskeletal conditions
A cross-sectional study of website claims related to diagnoses and treatment of nonmusculoskeletal conditions A total of 36 (26%) of the sampled chiropractic websites in Denmark mentioned diagnoses or symptoms of non-musculoskeletal origin on their websites without presenting an adequate clarifying explanation in agreement with the chiropractic scope of practice as defined by the Danish […]
Advances in the understanding and treatment of pain and headache
Advances in the understanding and treatment of pain and headache In conclusion, I am very grateful to all the authors who agreed to share their deep knowledge on pain and headache in the frame of this special issue. As it is, the issue collects an original set of insightful opinion articles and reviews that attempt […]
There is limited existing evidence to support the common assumption that strenuous endurance exercise bouts impair immune competency
There is limited existing evidence to support the common assumption that strenuous endurance exercise bouts impair immune competency In summary, based on current evidence, it is misleading to state that any form of exercise is immuno-suppressive. This belief is counterproductive for encouraging exercise as a preventative and therapeutic strategy for chronic disease. Indeed, we encourage […]