Research Posts

Muscle Atrophy Induced by Mechanical Unloading: Mechanisms and Potential Countermeasures
Muscle Atrophy Induced by Mechanical Unloading: Mechanisms and Potential Countermeasures Recent advancements in understanding of cellular and molecular mechanisms, including IGF1-Akt-mTOR, MuRF1/MAFbx, FOXO, and potential triggers of disuse atrophy, such as calcium overload and ROS overproduction, as well as their role in skeletal muscle protein adaptation to disuse is emphasized. We have also elaborated potential […]
A Tale of Specialization in 2 Professions: Comparing the Development of Radiology in Chiropractic and Medicine
A Tale of Specialization in 2 Professions: Comparing the Development of Radiology in Chiropractic and Medicine n this tale of 2 professions, radiology gained official specialty designation in the field of medicine. The medical profession had a monopoly on health care, and thus had few internal and external barriers to overcome. Chiropractic was oppressed by […]
Vitamin D and Calcium for the Prevention of FractureA Systematic Review and Meta-analysis
Vitamin D and Calcium for the Prevention of FractureA Systematic Review and Meta-analysis n this systematic review and meta-analysis, neither intermittent nor daily dosing with standard doses of vitamin D alone was associated with reduced risk of fracture, but daily supplementation with both vitamin D and calcium was a more promising strategy. #science #chiropractor #chiropractic […]
Taking Antioxidants During Chemo Has Negative Effects
Taking Antioxidants During Chemo Has Negative Effects #science #chiropractor #chiropractic #research #education #evidence based #patient centered #interprofessional #collaborative #rehabilitation #public health #spinal health #musculoskeletal health #ethics #pain #function #disability #QOL #knowledgetranslation
Development of a Clinical Decision Aid for Chiropractic Management of Common Conditions Causing Low Back Pain in Veterans: Results of a Consensus Process
Development of a Clinical Decision Aid for Chiropractic Management of Common Conditions Causing Low Back Pain in Veterans: Results of a Consensus Process This study group produced a chiropractic clinical decision aid for LBP management, which can be used to support evidence-based care decisions for veterans with LBP. #science #chiropractor #chiropractic #research #education #evidence based […]
Improvements in clinical pain and experimental pain sensitivity after cognitive functional therapy in patients with severe persistent low back pain
Improvements in clinical pain and experimental pain sensitivity after cognitive functional therapy in patients with severe persistent low back pain Patients receiving CFT showed significant improvements in pain intensity, pain-related disability, pain-related cognitions, emotions, QOL, use of opioids, and PPTs. The CFT pathway produced superior outcomes for pain-related disability and QOL at a much lower […]
An enactive approach to pain: beyond the biopsychosocial mode
An enactive approach to pain: beyond the biopsychosocial mode Considering the limitations of the pain theories presented, an enactive approach to pain was explored as an alternative big picture framework. Informed by established theory and research by phenomenologists and cognitive scientists, pain was described as: (1) Embodied, (2) Embedded, (3) Enacted, (4) Emotive, and (5) […]
A Mediational Analysis of Stress, Inflammation, Sleep, and Pain in Acute Musculoskeletal Trauma
A Mediational Analysis of Stress, Inflammation, Sleep, and Pain in Acute Musculoskeletal Trauma "In this study, participant ratings of mean general life stress in the 6 months prior to non-catastrophic MSK trauma significantly predicted baseline pain severity as measured using the BPI Pain Severity subscale. Pre-trauma life stress also predicted the score on the BPI […]
Effects of Intermittent Fasting on Health, Aging, and Disease List of authors.
Effects of Intermittent Fasting on Health, Aging, and Disease List of authors. Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-based energy, with increased stress resistance, increased longevity, and a decreased incidence of diseases, including cancer and obesity. #science #chiropractor #chiropractic […]
Best-Practice Recommendations for Chiropractic Management of Patients With Neck Pain
Best-Practice Recommendations for Chiropractic Management of Patients With Neck Pain These best-practice recommendations for chiropractic management of adults with neck pain are based on the best available scientific evidence. For uncomplicated neck pain, including neck pain with headache or radicular symptoms, chiropractic manipulation and multimodal care are recommended. #science #chiropractor #chiropractic #research #education #evidence based […]
Cervico-ocular reflex upregulation in dizzy patients with asymmetric neck pathology
Cervico-ocular reflex upregulation in dizzy patients with asymmetric neck pathology Patients with asymmetric restriction in neck rotation and increased neck muscle tension reveal the tendency to have an increased response of the vestibular system, along with co-existing COR upregulation. Further research is needed to investigate the relationships between the activation of cervical mechanoreceptors and dizziness […]
Muscle Cramping During Exercise: Causes, Solutions, and Questions Remaining
Muscle Cramping During Exercise: Causes, Solutions, and Questions Remaining Exercise-associated muscle cramp is a relatively common occurrence in a range of sport and exercise activities. Onset is generally unpredictable, and the intensity and duration of muscle spasms are highly variable. Spontaneous muscle cramping in occupational settings involving hard physical effort suggests that high ambient temperature […]
Opioids for chronic osteoarthritis pain: An updated systematic review and meta‐analysis of efficacy, tolerability and safety in randomized placebo‐controlled studies of at least 4 weeks double‐blind duration
Opioids for chronic osteoarthritis pain: An updated systematic review and meta‐analysis of efficacy, tolerability and safety in randomized placebo‐controlled studies of at least 4 weeks double‐blind duration Tolerability of opioids is low and efficacy is not clinically relevant in controlled studies from 4 to 24 weeks for osteoarthritis pain. #science #chiropractor #chiropractic #research #education #evidence […]
Cost-Efficiency and Effectiveness of Including Doctors of Chiropractic to Offer Treatment Under Medicaid: A Critical Appraisal of Missouri Inclusion of Chiropractic Under Missouri Medicaid.
Cost-Efficiency and Effectiveness of Including Doctors of Chiropractic to Offer Treatment Under Medicaid: A Critical Appraisal of Missouri Inclusion of Chiropractic Under Missouri Medicaid. Policymakers may unintentionally rely on flawed assumptions and methodologies such as static scoring, which we propose results in flawed conclusions. Legislative options involve some additional cost. The issue is whether proposed […]
Addition of blood flow restriction to passive mobilization reduces the rate of muscle wasting in elderly patients in the intensive care unit: a within-patient randomized trial
Addition of blood flow restriction to passive mobilization reduces the rate of muscle wasting in elderly patients in the intensive care unit: a within-patient randomized trial The use of blood flow restriction did not present adverse effects and seems to be a valid strategy to reduce the magnitude of the rate of muscle wasting that […]
Fighting Injustice: A Historical Review of the National Chiropractic Antitrust Committee.
Fighting Injustice: A Historical Review of the National Chiropractic Antitrust Committee. The NCAC was successful in its mission to raise funds to support the 2 trials of the Wilk et al v AMA et al lawsuit, multiple appeals, and post-trial distribution of funds donated by the plaintiffs to support charity work for children and chiropractic research. Without […]
Patient Information Leaflets for LumbarSpine Surgery: A Missed Opportunity
Patient Information Leaflets for LumbarSpine Surgery: A Missed Opportunity The rationale for needing high-quality preoperative patient information is well-documented; however, there is considerable variation in the quality of the leaflets provided ahead of lumbar spine surgery. Particular areas that were identified as requiring improvement were the provision of the sources of information, the delivery of […]
Discovery of a new ligament of the lumbar spine: the midline interlaminar ligament
Discovery of a new ligament of the lumbar spine: the midline interlaminar ligament Based on our findings, a distinct MIL was identified in the lumbar spine at the majority of lumbar levels. #science #chiropractor #chiropractic #research #education #evidence based #patient centered #interprofessional #collaborative #rehabilitation #public health #spinal health #musculoskeletal health #ethics #pain #function #disability #QOL […]
Current Evidence for Diagnosis of Common Conditions Causing Low Back Pain: Systematic Review and Standardized Terminology Recommendations.
Current Evidence for Diagnosis of Common Conditions Causing Low Back Pain: Systematic Review and Standardized Terminology Recommendations. The absence of high-quality, objective, gold-standard diagnostic methods limits the accuracy of current evidence-based criteria and results in few high-quality studies with a low risk of bias in patient selection and reference standard diagnosis. These limitations suggest practitioners […]
The Elephant in the Room: Too Much Medicine in Musculoskeletal Practice
The Elephant in the Room: Too Much Medicine in Musculoskeletal Practice Too much medicine burdens health care systems and deprives societies of resources. Overcoming too much medicine requires stakeholders (patients, clinicians, educators, health care funders, media, policy makers, industry, insurers, politicians, etc) to appropriately prioritize low-risk, cost-effective care over higher-risk and more expensive care of […]
Changes in Quality of Care after Hospital Mergers and Acquisitions
Changes in Quality of Care after Hospital Mergers and Acquisitions Hospital acquisition by another hospital or hospital system was associated with modestly worse patient experiences and no significant changes in readmission or mortality rates. Effects on process measures of quality were inconclusive. #science #chiropractor #chiropractic #research #education #evidence based #patient centered #interprofessional #collaborative #rehabilitation #public […]
Microbiota impacts on chronic inflammation and metabolic syndrome – related cognitive dysfunction
Microbiota impacts on chronic inflammation and metabolic syndrome - related cognitive dysfunction The study of different mouse models has contributed to identify characteristic microbiota profiles and shifts in the microbial gene richness in association with cognitive function. Diet, exercise and prebiotics, probiotics or symbiotics significantly influence cognition and changes in the microbiota. Few studies have […]
Comparing meta-analyses and preregistered multiple-laboratory replication projects
Comparing meta-analyses and preregistered multiple-laboratory replication projects We compare the results of meta-analyses to large-scale preregistered replications in psychology carried out at multiple laboratories. The multiple-laboratory replications provide precisely estimated effect sizes that do not suffer from publication bias or selective reporting. We searched the literature and identified 15 meta-analyses on the same topics as […]
Association Between Self-Reported Spinal Morning Stiffness and Radiographic Evidence of Lumbar Disk Degeneration in Participants of the Cohort Hip and Cohort Knee (CHECK) Study
Association Between Self-Reported Spinal Morning Stiffness and Radiographic Evidence of Lumbar Disk Degeneration in Participants of the Cohort Hip and Cohort Knee (CHECK) Study This study showed an association between self-reported spinal morning stiffness and symptomatic LDD. When morning stiffness lasted > 30 minutes, there was a significant association with the features of LDD. The […]
The Neural Processes of Acquiring Placebo Effects Through Observation
The Neural Processes of Acquiring Placebo Effects Through Observation Our findings provide an understanding of the neural processes during the acquisition of placebo effects through observation and indicate a critical role for DLPFC-TPJ integration processes during observational learning of therapeutic outcomes. #science #chiropractor #chiropractic #research #education #evidence based #patient centered #interprofessional #collaborative #rehabilitation #public health […]
Infographic. Is running associated with a lower risk of all-cause, cardiovascular and cancer mortality, and is more better? A systematic review and meta-analysis
Infographic. Is running associated with a lower risk of all-cause, cardiovascular and cancer mortality, and is more better? A systematic review and meta-analysis #science #chiropractor #chiropractic #research #education #evidence based #patient centered #interprofessional #collaborative #rehabilitation #public health #spinal health #musculoskeletal health #ethics #pain #function #disability #QOL #knowledgetranslation
Craniosacral therapy for chronic pain: a systematic review and meta-analysis of randomized controlled trials
Craniosacral therapy for chronic pain: a systematic review and meta-analysis of randomized controlled trials In patients with chronic pain, this meta-analysis suggests significant and robust effects of CST on pain and function lasting up to six months. More RCTs strictly following CONSORT are needed to further corroborate the effects and safety of CST on chronic […]
How fast pain, numbness, and paresthesia resolves after lumbar nerve root decompression: a retrospective study of patient’s self-reported computerized pain drawing
How fast pain, numbness, and paresthesia resolves after lumbar nerve root decompression: a retrospective study of patient's self-reported computerized pain drawing In lumbar radiculopathy patients after surgical decompression, pain recovers fastest, in the first 6 weeks postoperatively, followed by paresthesia recovery that plateaus at 3 months postoperatively. Numbness recovers at a slower pace but continues […]
Chronic physical illnesses, mental health disorders, and psychological features as potential risk factors for back pain from childhood to young adulthood: a systematic review with meta-analysis
Chronic physical illnesses, mental health disorders, and psychological features as potential risk factors for back pain from childhood to young adulthood: a systematic review with meta-analysis Psychological features are the most likely risk factors for back pain in young people. Several other factors were associated with back pain, but their potential as risk factors was […]
More Than a 2-Fold Risk of Contralateral Anterior Cruciate Ligament Injuries Compared With Ipsilateral Graft Failure 10 Years After Primary Reconstruction.
More Than a 2-Fold Risk of Contralateral Anterior Cruciate Ligament Injuries Compared With Ipsilateral Graft Failure 10 Years After Primary Reconstruction. In the long term, a second injury to either the ipsilateral or the contralateral knee in young and active populations could reach 40%, with a more than double-fold risk of contralateral ACL reconstruction compared […]