Trends in Intentional and Unintentional Opioid Overdose Deaths in the United States, 2000-2017 Increasing rates of opioid overdose and suicide deaths have fueled interest in defining the extent to which these 2 urgent public health problems are syndemic. Although it has been assumed that approximately one-quarter of opioid overdose deaths are intentional,1 prior research has not evaluated the national distribution of opioid-related deaths by manner. Reevaluation of officially classified poisoning deaths of undetermined intent suggests that 21% may be misclassified suicides.2 We evaluated trends in US drug overdose deaths involving opioids certified as unintentional, suicide, or undetermined intent.
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